Citric Acid Cycle (Kreb’s Cycle) Song

In mitochondria
A cycle of reactions
Turns food you eat into
Makes ATP energy

Two CO2 are made
And three NADH
One FADH2
And one ATP energy

After glycolysis
Before ETC happens
A cycle of reactions
Makes ATP energy

Two CO2 are made
And three NADH
One FADH2
And one ATP energy

Before the cycle starts
Back out to glycolysis
Makes two 3-carbon pyruvates
Lose a carbon, makes a, acetyl CoA
Carbon dioxide out your breath as waste

This cycle regenerates
Oxaloacetate
Enzymes fuse it with CoA
To form citric acid, citrate

A six-carbon molecule, three carboxyl groups
Atoms up rearranged, now it’s isocitrate
Oxidation takes a carbon combines it with oxygen
CO2 is produced, waste it out releases it

High energy, NAD+ gains
An electron and become NADH
Five-carbon A-ketoglutarate
Lose a CO2, a new NADH made

Coenzyme A grabbed up, unstable
And how many carbons we got? We got four
succinyl CoA enzyme used toward
New oxidation, energy transformed

That synthetase removes the CoA
Produce a GTP with add of a phosphate
So GTP and ATP, they’re similar, not the same thing
Depending on the cell, G may convert to ATP

And now that CoA gone, clears away
Molecule rearranged becomes a succinate
Dehydrate with succinate dehydrogenase helps reduce
An FAD move to an FADH2

And now we looking at a fumarate, hydrate
By fumarase enzyme to make malate
It’s rearranged, dehydrogenase
Back to the OG oxaloacetate

That’s one full cycle one time
But remember that glucose was split in two
The next 3-carbon in line
The other pyruvate still got to go on through

In mitochondria
A cycle of reactions
Turns food you eat into
Makes ATP energy

Two CO2 are made
And three NADH
One FADH2
And one ATP energy

After glycolysis
Before ETC happens
A cycle of reactions
Makes ATP energy

Two CO2 are made
And three NADH
One FADH2
And one ATP energy